FLT3 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human;Mouse
- 应用性： IHC
| Verified Samples |
Verified Samples in IHC:Human thyroid cancer,Human brain |
| Dilution | IHC 1:50-1:200 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein of human FLT3 |
| Abbre | FLT3 |
| Synonyms | CD 135;CD135;CD135 antigen;Fetal liver kinase 2;FL cytokine receptor;Flk 2;Flk2;Flt 3;FLT-3;Flt3;FLT3;FMS like tyrosine kinase 3;Fms related tyrosine kinase 3;Fms-like tyrosine kinase 3;Growth factor receptor tyrosine kinase type III;Ly-72;OTTHUMP0000004234;Receptor type tyrosine protein kinase FLT3;Stem cell tyrosine kinase 1;Stk 1;STK-1;Stk1;Tyrosine protein kinase receptor FLT3;Tyrosine-protein kinase receptor FLT3 |
| Swissprot | |
| Cellular Localization | Membrane. |
| Concentration | 0.5 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Immunology; Signal Transduction |
| Conjugation | Unconjugated |
| Background | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using FLT3 Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human brain tissue using FLT3 Polyclonal Antibody at dilution 1:50
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
