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Glucocorticoid Receptor Polyclonal Antibody

Price: ¥3300 ¥2220 ¥1380

Size:
200μL 120μL 60μL
  • 宿主: Rabbit
  • 反应性: Human;Mouse;Rat
  • 应用性: WB;IHC
Verified Samples
Verified Samples in WB:Mouse heart,HepG2,MCF-7,Mouse Heart,Mouse kidney,Mouse brain,Rat heart,Rat kidney
Verified Samples in IHC:Mouse liver,Rat spleen
Dilution
WB 1:500-1:1000;IHC 1:500-1:1000
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant proteincorresponding to Mouse Glucocorticoid receptor
Abbre
Glucocorticoid Receptor
Synonyms
GCCR;GCR;GCR;GCRST;glucocorticoid nuclear receptor variant 1;Glucocorticoid receptor;GR;GRL;Grl1;nr3c1;Nuclear receptor subfamily 3 group C member 1;nuclear receptor subfamily 3;group C;member 1 (glucocorticoid receptor)抗体
Swissprot
Calculated MW
91kDa
Observed MW
91kDa
Cellular Localization
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus.
Concentration
1.3 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Purification Method
Affinity purification
Research Areas
Cancer; Epigenetics and Nuclear Signaling; Signal Transduction
Conjugation
Unconjugated
Background
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.
Western Blot analysis of various samples using Glucocorticoid Receptor Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded mouse liver using Glucocorticoid Receptor Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of paraffin-embedded rat spleen using Glucocorticoid Receptor Polyclonal Antibody at dilution of 1:1000.


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