HAND1 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human; Mouse; Rat
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB:Human fetal brain Verified Samples in IHC:Human esophagus cancer,Human brain |
| Dilution | WB 1:500-1:2000;IHC 1:20-1:100 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide of human HAND1 |
| Abbre | HAND1 |
| Synonyms | autonomic nervous system and neural crest derivatives-expressed protein 1;Basic helix loop helix transcription factor HAND1;bHLHa27;Class A basic helix-loop-helix protein 27;eHAND;Extraembryonic tissues;Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1;HAND 1;HAND1;HAND1;Heart and neural crest derivatives expressed 1;Heart and neural crest derivatives expressed protein 1;heart;Heart- and neural crest derivatives-expressed protein 1;Hxt;Thing 1;Thing1 ;Thing1 |
| Swissprot | |
| Calculated MW | 24 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Nucleus>nucleoplasm. Nucleus>nucleolus. Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity. |
| Concentration | 0.9 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling;Stem Cells;Cardiovascular;Developmental Biology |
| Conjugation | Unconjugated |
| Background | The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. |
Western blot analysis of Human fetal brain tissue lysateusing HAND1 Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissueusing HAND1 Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human brain tissueusing HAND1 Polyclonal Antibody at dilution of 1:30(×200)
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
