HTRA1 Polyclonal Antibody
Price:
Size:
100μL
50μL
- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC
Verified Samples |
Verified Samples in WB:Mouse placenta,Rat placenta Verified Samples in IHC:Human placenta |
Dilution | WB:1:500-1:1000,IHC 1:400-1:800 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human HTRA1 protein expressed by E.coli |
Abbre | HTRA1 |
Synonyms | Serine protease HTRA1; High-temperature requirement A serine peptidase 1; L56; Serine protease 11; PRSS11 |
Swissprot | |
Calculated MW | 51 kDa |
Observed MW | 51 kDa |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH 7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Signal transduction |
Conjugation | Unconjugated |
Background | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
Western blot with HTRA1 Polyclonal antibody at dilution of 1:500.lane 1:Mouse placenta, lane 2:Rat placenta
Immunohistochemistry of paraffin-embedded Human placenta using HTRA1 Polyclonal Antibody at dilution of 1:800
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |