IL10 Polyclonal Antibody

货号：E-AB-70235
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说明书

说明书

Price: ¥3300 ¥2220 ¥1380

Size:

200μL 120μL 60μL

宿主： Rabbit
反应性： Mouse;Rat
应用性： IHC;IF

Verified Samples	Verified Samples in IHC:Mouse lungs Verified Samples in IF:Rat Inflammatory lung
Dilution	IHC 1:200-1:1000;IF 1:200-1:1000
Clonality	Polyclonal
Isotype	IgG
Immunogen	KLH conjugated Synthetic peptide corresponding to IL-10
Abbre	IL10
Synonyms	CSIF;Cytokine synthesis inhibitory factor;GVHDS;IL 10;IL-10;IL10;IL10;IL10A;Interleukin 10;Interleukin-10;MGC126450;MGC126451;T-cell growth inhibitory factor;TGIF抗体
Swissprot	P18893 ,P29456
Cellular Localization	Secreted.
Concentration	150 μg/mL
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer	PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Purification Method	Affinity purification
Research Areas	Cancer; Immunology
Conjugation	Unconjugated
Background	Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Immunohistochemistry analysis of paraffin-embedded mouse lungs using IL10 Polyclonal Antibody at dilution of 1:300.

Immunofluorescence analysis of paraffin-embedded rat Inflammatory lung using IL10 Polyclonal Antibody at dilution of 1:300.

Interleukin 10 Attenuates Angiotensin II-Induced Aortic Remodelling by Inhibiting Oxidative Stress-Induced Activation of the Vascular p38 and NF-κB Pathways

IF: 6.543

Journal：Oxidative Medicine and Cellular Longevity

DOI：10.1155/2022/8244497

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