LEPR Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB:293T Verified Samples in IHC:Human liver cancer |
| Dilution | WB 1:500-1:2000;IHC 1:40-1:200 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide of human LEPR |
| Abbre | LEPR |
| Synonyms | CD 295;CD295;CD295 antigen;Db;Fa;HuB219;LEP R;LEP-R;LEPR;LEPR;LEPRD;Leptin receptor;Leptin receptor fatty;Leptin receptor gene related protein;Leptin receptor precursor;Leptin receptor precursor;OB R gene related protein;OB receptor;OB-R;OB-RGRP;obl;Obr抗体 |
| Swissprot | |
| Calculated MW | 133 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Secreted and Cell membrane. |
| Concentration | 0.84 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer; Cardiovascular; Metabolism; Signal Transduction |
| Conjugation | Unconjugated |
| Background | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021). |
Western blot analysis of 293T cell lysate using LEPR Polyclonal Antibody at dilution of 1:250
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LEPR Polyclonal Antibody at dilution of 1:30(×200)
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Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice
IF: 2.823Journal：MOLECULAR REPRODUCTION AND DEVELOPMENT
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