MutL Protein Homolog 1(MLH1) Monoclonal Antibody
Price:
Size:
200μL
100μL
6mL
3mL
- 宿主： Mouse
- 反应性： Human
- 应用性： IHC-P
| Verified Samples |
Verified Samples in IHC:Human colon cancer tissue |
| Size |
3mL/6mL(即用型);100μL/200μL(浓缩型) |
| Clonality | Monoclonal |
| Abbre | MutL Protein Homolog 1(MLH1) |
| Synonyms | COCA 2,COCA2,DNA mismatch repair protein Mlh1,FCC 2,FCC2,hMLH 1,hMLH1,HNPCC 2,HNPCC,HNPCC2,MGC5172,MLH 1,MLH1,MLH1,MutL homolog 1 (E. coli),MutL homolog 1,MutL homolog 1 colon cancer nonpolyposis type 2,MutL homolog 1,colon cancer,nonpolyposis type 2 (E. coli),MutL protein homolog 1,MutL,E. coli,homolog of,1 |
| Swissprot | |
| Cellular Localization | Nucleus |
| Storage | The concentrated should be stored at -20°C protecting from light,The RTU should be stored at 2~8°C protecting from light (Do not freeze).Valid for 12 months. |
| Research Areas | Cancer;Epigenetics and Nuclear Signaling |
| Clone No. | YN01116m |
| Conjugation | Unconjugated |
| Background | MLH1是一种错配修复基因，定位在3号染色体的P臂21.3位上。DNA错配修复对于超时遗传信息完整性的维持是非常必要的。微卫星重现性的改变是由于DNA复制时铰链不对位产生滑动而导致的，又称为微卫星不稳定性，这些DNA修复通路的缺陷和一些人类肿瘤相关。突变型的错配修复基因常表达于高频度微卫星不稳定（MSI-H）患者中，与常染色体的显性遗传性疾病相关，称为遗传性非息肉病性结、直肠癌（HNPCC），也可见于散发性（MSI-H）结、直肠癌患者。MLH1、MSH2、MSH6抗体可用于患者及其家族对该疾病的筛查。文献报道高频度微卫星不稳定（MSI-H）的结、直肠癌患者比低频度微卫星不稳定性（MSI-L）及微卫星稳定（MSS）的患者的预后好。 |
福尔马林固定，石蜡包埋，EDTA修复，人体结肠癌组织MLH1染色。
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
