Phospho-ERK 1/2 (Tyr222/205) Monoclonal Antibody
Price:
Size:
120μL
60μL
20μL
- 宿主: Mouse
- 反应性: Human;Mouse;Rat
- 应用性: IHC-p
Verified Samples |
Verified Samples in IHC:Human colon carcinoma,Human breast carcinoma |
Dilution | IHC 1:100-200 |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205) |
Abbre | Phospho-ERK 1/2 (Tyr222/205) |
Synonyms | MAPK3;ERK1;PRKM3;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p抗体 |
Swissprot | |
Cellular Localization | Nucleus. |
Concentration | 1mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
Purification Method | Protein A purification |
Research Areas | Cancer;Signal Transduction;Neuroscience |
Clone No. | Clone:4D4 |
Conjugation | Unconjugated |
Background | Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. |
Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue with Phospho-ERK 1/2 (Tyr222/205) Monoclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue with Phospho-ERK 1/2 (Tyr222/205) Monoclonal Antibody at dilution of 1:200
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