Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)
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- 表达系统： P.Pichia
- 蛋白编码： H0VUB1
- 应用性： Cell culture
| 别称 |
Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA-4;CD152;CTLA4
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| 表达系统 |
P.Pichia
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| 序列 |
Ala37-Asp161
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| 蛋白编码 |
H0VUB1
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| 种属 |
Cavia porcellus
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| 计算分子量 |
16-35 kDa
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| 表观分子量 |
18-40 kDa
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| 标签 |
C-His
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| 生物活性 |
Immobilized Mouse B7-1-Fc at 5 μg/ml (100 μl/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Recombinant Cavia porcellus CTLA-4-His is 4.29 ng/ml.
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| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
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实验操作视频
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