Recombinant Human Carboxylesterase 1/CES1 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P23141-3
| 别称 |
Liver Carboxylesterase 1;Acyl-Coenzyme A:Cholesterol Acyltransferase;ACAT;Brain Carboxylesterase hBr1;Carboxylesterase 1;CE-1;hCE-1;Cocaine Carboxylesterase;Egasyn;HMSE;Methylumbelliferyl-Acetate Deacetylase 1;Monocyte/Macrophage Serine Esterase;Retinyl Ester Hydrolase;REH;Serine Esterase 1;Triacylglycerol Hydrolase;TGH;CES1;CES2;SES1
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| 表达系统 |
HEK293 Cells
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| 序列 |
His19-Glu562
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| 蛋白编码 |
P23141-3
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| 种属 |
Human
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| 计算分子量 |
61.1 kDa
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| 表观分子量 |
60 kDa
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| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.0.
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| 复溶方法 |
Not Applicable
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| 背景 |
Carboxylesterase 1 (CES1) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. These enzymes have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They are major determinants of the pharmacokinetic behavior of most therapeutic agents containing an ester or amide bond. CES1 shares the serine hydrolase fold observed in other esterases. CES1 hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. CES1 participates in detoxification of drugs such as cocaine and heroin in serum and liver. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
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实验操作视频
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