Recombinant Human Caspase-10/CASP10 Protein (His Tag)
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- 表达系统： E.coli
- 蛋白编码： Q92851-4
| 别称 |
Caspase-10;CASP-10;Apoptotic Protease Mch-4;FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2;FLICE2;ICE-Like Apoptotic Protease 4;CASP10;MCH4
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| 表达系统 |
E.coli
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| 序列 |
Val220-Ile480
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| 蛋白编码 |
Q92851-4
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| 种属 |
Human
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| 计算分子量 |
30.1 kDa
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| 表观分子量 |
33 kDa
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| 标签 |
C-His
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| 纯度 |
> 70 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 1mM DTT, 0.05% Tween 80, pH8.5.
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| 复溶方法 |
Not Applicable
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| 背景 |
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). CASP10 cleaves and activates caspases 3 and 7, but itself is processed by caspase 8. Defects in CASP10 are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.
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实验操作视频
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