Recombinant Human Cyclophilin A Protein
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- 表达系统： E.coli
- 蛋白编码： P62937
| 别称 |
Peptidyl-prolyl cis-trans isomerase A;PPIase A;Cyclophilin A;Cyclosporin A-binding protein;Rotamase A;SP18;PPIA;CYPA
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| 表达系统 |
E.coli
|
| 序列 |
Met 1-Glu165
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| 蛋白编码 |
P62937
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| 种属 |
Human
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| 计算分子量 |
18.0 kDa
|
| 表观分子量 |
16 kDa
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| 标签 |
None
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
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实验操作视频
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