Recombinant Human Gankyrin/PSDM10 Protein
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- 表达系统： E.coli
- 蛋白编码： O75832
| 别称 |
26S Proteasome Non-ATPase Regulatory Subunit 10;26S Proteasome Regulatory Subunit p28;Gankyrin;p28(GANK);PSMD10
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| 表达系统 |
E.coli
|
| 序列 |
Met 1-Gly226
|
| 蛋白编码 |
O75832
|
| 种属 |
Human
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| 计算分子量 |
24.4 kDa
|
| 表观分子量 |
26 kDa
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| 标签 |
None
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
|
| 复溶方法 |
Not Applicable
|
| 背景 |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
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实验操作视频
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