Recombinant Human IFNAR2 Protein (His Tag)
Price:
- 表达系统： HEK293 Cells
- 蛋白编码： P48551
| 别称 |
Interferon Alpha/Beta Receptor 2;IFN-R-2;IFN-Alpha Binding Protein;IFN-Alpha/Beta Receptor 2;Interferon Alpha Binding Protein;Type I Interferon Receptor 2;IFNAR2;IFNABR;IFNARB
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ile27-Lys243
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| 蛋白编码 |
P48551
|
| 种属 |
Human
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| 计算分子量 |
25.8 kDa
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| 表观分子量 |
38-55 kDa
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| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interferon α/β Receptor 2 (IFN-α/β R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-α/β R1 to form the signaling receptor complex for the family of α and β IFN subtypes. By alternative splicing; IFN-α/β R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-α/β R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-α/β R1; resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes; monocytes; and granulocytes; although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets; IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase; JAK1. Isoform 1 also interacts with the transcriptional factors; STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
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实验操作视频
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