Recombinant Human IMP1/IMPA1 Protein (His Tag)
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- 表达系统： E.coli
- 蛋白编码： P29218
| 别称 |
Inositol Monophosphatase 1;IMP 1;IMPase 1;Inositol-1(or 4)-Monophosphatase 1;Lithium-Sensitive Myo-Inositol Monophosphatase A1;IMPA1;IMPA
|
| 表达系统 |
E.coli
|
| 序列 |
Met 1-Asp277
|
| 蛋白编码 |
P29218
|
| 种属 |
Human
|
| 计算分子量 |
32.3 kDa
|
| 表观分子量 |
30 kDa
|
| 标签 |
N-His
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.25.
|
| 复溶方法 |
Not Applicable
|
| 背景 |
Inositol Monophosphatase 1 (IMPA1) belongs to the inositol monophosphatase family. IMPA1 is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, IMPA1 can use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. IMPA1 has been implicated as the pharmacological target for lithium action in brain. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. In addition, IMPA1 plays a improtant role in intracellular signal transduction.
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实验操作视频
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