Recombinant Human Interleukin-17A/IL-17A Protein
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- 表达系统： E.coli
- 蛋白编码： Q16552
- 应用性： Cell culture
| 别称 |
Interleukin-17A;IL-17;IL-17A;Cytotoxic T-Lymphocyte-Associated Antigen 8;CTLA-8;IL17A;CTLA8;IL17
|
| 表达系统 |
E.coli
|
| 序列 |
Ile20-Ala155
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| 蛋白编码 |
Q16552
|
| 种属 |
Human
|
| 计算分子量 |
16.5 kDa
|
| 表观分子量 |
17 kDa
|
| 标签 |
C-His
|
| 生物活性 |
Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is <6 ng/mL.
|
| 纯度 |
> 98 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.01 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from sterile PBS,pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha; it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis; and produced by rheumatoid arthritis synovium. It increases IL-6 production; induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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实验操作视频
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