Recombinant Human NOL3 Protein
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- 表达系统： E.coli
- 蛋白编码： O60936
| 别称 |
Nucleolar Protein 3;Apoptosis Repressor With CARD;Muscle-Enriched Cytoplasmic Protein;Myp;Nucleolar Protein of 30 kDa;Nop30
|
| 表达系统 |
E.coli
|
| 序列 |
Met 1-Ser208
|
| 蛋白编码 |
O60936
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| 种属 |
Human
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| 计算分子量 |
22.6 kDa
|
| 表观分子量 |
29 kDa
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| 标签 |
None
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| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mm NaCl, 1mM DTT, 1mM EDTA, 10% Glycerol, pH7.0.
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| 复溶方法 |
Not Applicable
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| 背景 |
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far; Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly; it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner; limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2; caspase 8 and tumor protein p53.
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实验操作视频
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