Recombinant Human P-glycoprotein1/ABCB1 protein (His tag)
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- 表达系统: E.coli
- 蛋白编码: P08183
别称 |
ATP-dependent translocase ABCB1;ABCB1;ATP-binding cassette sub-family B member 1;P-glycoprotein 1;Phospholipid transporter ABCB1;CD243;
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表达系统 |
E.coli
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序列 |
Leu 392-Met 628
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蛋白编码 |
P08183
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种属 |
Human
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计算分子量 |
26.0 kDa
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表观分子量 |
32 kDa
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标签 |
N-His
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纯度 |
> 95 % as determined by reducing SDS-PAGE.
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内毒素 |
Please contact us for more information.
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保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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制剂 |
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
复溶方法 |
Please refer to the printed manual for detailed information.
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背景 |
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996).
Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203).
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996).
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实验操作视频
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