Recombinant Human TIM-3/HAVCR2 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： AAL65157.1
- 应用性： ELISA
| 别称 |
Hepatitis A Virus Cellular Receptor 2;HAVcr-2;T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3;TIMD-3;T-Cell Membrane Protein 3;TIM-3;HAVCR2;TIM3;TIMD3
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ser22-Arg200
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| 蛋白编码 |
AAL65157.1
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| 种属 |
Human
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| 计算分子量 |
20.9 kDa
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| 表观分子量 |
37 kDa
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| 标签 |
C-His
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| 生物活性 |
Immobilized Anti-Human TIM-3 mAb at 2μg/ml (100 μl/well) can bind Human TIM-3-His. The ED50 of Recombinant Human TIM-3-His is 8.51ng/ml.
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
T-Cell Membrane Protein 3 (TIM3) is a single-pass type I membrane protein that belongs to the TIM family of immunoglobulin superfamily. TIM3 includes a signal sequence (aa 1-21); an extracellular region (aa 22-202) with one Ig-like V-type domain; a transmembrane segment (aa 203-223); and a cytoplasmic domain (aa 224 - 301). TIM3 regulates macrophage activation; inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and as a receptor for LGALS9.
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实验操作视频
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