Recombinant Human TNFSF14/LIGHT Protein (mFc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： AAC39563.1
| 别称 |
CD258;HVEML;LIGHT;LTg;TR2;Tumor necrosis factor ligand superfamily member 14;Herpes virus entry mediator ligand;TNFSF14;HVEM-L;LIGHT
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ile84-Val240
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| 蛋白编码 |
AAC39563.1
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| 种属 |
Human
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| 计算分子量 |
43.3 kDa
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| 表观分子量 |
45-60 kDa
|
| 标签 |
N-mFc
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| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
Human TNFSF14 Protein; also known as LIGHT; belongs to a member of the tumor necrosis factor (TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14; which is a member of the tumor necrosis factor receptor superfamily; and it is also known as a herpesvirus entry mediator ligand (HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain; 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart; placenta; liver; lung; appendix; and kidney; and no expression seen in fetal tissues; endocrine glands; or nonhematopoietic tumor lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
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实验操作视频
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