Recombinant Mouse OX40/TNFRSF4 Protein (His Tag)
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- 表达系统: HEK293 Cells
- 蛋白编码: P47741
- 应用性: BLI
别称 |
Tumor necrosis factor receptor superfamily member 4;Tnfrsf4;OX40;CD134;Txgp1
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表达系统 |
HEK293 Cells
|
序列 |
Val20-Pro211
|
蛋白编码 |
P47741
|
种属 |
Mouse
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计算分子量 |
22.1 kDa
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表观分子量 |
40 kDa
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标签 |
C-His
|
生物活性 |
Loaded Mouse OX40L-His on AR2G Biosensor, can bind Mouse OX40-His with an affinity constant of 0.16 uM as determined in BLI assay.
|
纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
复溶方法 |
Please refer to the printed manual for detailed information.
|
背景 |
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
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实验操作视频
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