Recombinant Rat SCF/c-Kit Ligand Protein (Human Cells, His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P21581
| 别称 |
FPH2;KIT ligand;Kitl;KITLG;KL-1;Mast cell growth factor;MGF;MGFSHEP7;SCF;SFc-Kit ligand;SLF;steel factor;Stem Cell Factor;c-kit Ligand
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln26-Ala189
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| 蛋白编码 |
P21581
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| 种属 |
Rat
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| 计算分子量 |
19.4 kDa
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| 表观分子量 |
23-40 kDa
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| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
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实验操作视频
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