STAT1 Polyclonal Antibody
Price:
Size:
100μL
50μL
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB:Mouse lung,Hela,A549 Verified Samples in IHC:Rat liver,Human spleen |
| Dilution | WB 1:500-1:1000;IHC 1:50-1:100 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant Human STAT1 Protein expressed by E.coli |
| Abbre | STAT1 |
| Synonyms | Signal transducer and activator of transcription 1 91kD;CANDF7;DKFZp686B04100;IMD31A;IMD31B;IMD31C;ISGF 3;ISGF-3;OTTHUMP00000163552;OTTHUMP00000165046;OTTHUMP00000165047;OTTHUMP00000205845;Signal transducer and activator of transcription 1 91kDa;Signal transducer and activator of transcription 1;Signal transducer and activator of transcription 1;91kD;Signal transducer and activator of transcription 1-alpha/beta;STAT 1;Stat1;STAT1;STAT91;Transcription factor ISGF 3 components p91 p84;Transcription factor ISGF-3 components p91/p84;STAT1 |
| Swissprot | |
| Calculated MW | 87kDa |
| Observed MW | 87kDa |
| Concentration | 1mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide,50% glycerol pH 7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer;Epigenetics and Nuclear Signaling;Signal Transduction |
| Conjugation | Unconjugated |
| Background | Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors,Jak kinases (TYK2 and JAK1) are activated,leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize,associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor,that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes,which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma),STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF),migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes,inducing a cellular antiviral state. |
Western blot with STAT1 Polyclonal antibody at dilution of 1:1000.lane 1:Mouse lung
Western blot with STAT1 Polyclonal antibody at dilution of 1:1000.lane 1:Hela whole cell lysate,lane 2:A549 whole cell lysate
Immunohistochemistry of paraffin-embedded Rat liver using STAT1 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry analysis of paraffin-embedded Human Spleen using STAT1 Polyclonal Antibody(Elabscience Product Detected by Lifespan).
| E-AB-1003 | Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500μL , 120μL , 60μL , 30μL , 1mL |
| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
