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STIL Polyclonal Antibody

Price: ¥2365 ¥1640 ¥1010 ¥420

Size:
200μL 120μL 60μL 20μL
  • 宿主: Rabbit
  • 反应性: Human
  • 应用性: IHC
Verified Samples
Verified Samples in IHC:Human lung
Dilution
IHC 1:50-1:200
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant Human SCL-interrupting locus protien
Abbre
STIL
Synonyms
DKFZp686O09161;MCPH7;OTTHUMP00000009566;SCL interrupting locus protein;SCL-interrupting locus protein;SCL/TAL1 interrupting locus;SIL;STIL;STIL_HUMAN;TAL 1 interrupting locus protein;TAL-1-interrupting locus protein抗体
Swissprot
Cellular Localization
Cytoplasm
Concentration
2 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification Method
Affinity purification
Research Areas
Cell Biology;Stem Cells
Conjugation
Unconjugated
Background
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunohistochemistry of paraffin-embedded Human lung using STIL Polyclonal Antibody at dilution of 1:200


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