TIMP-2/TIMP2 Polyclonal Antibody
Price:
Size:
100μg
25μg
- 宿主： Rabbit
- 反应性： Human;Mouse;Rat
- 应用性： WB
| Verified Samples |
Verified Samples in WB:Human Hela,Human SH-SY5Y,Human A431,Rat C6,Human U-20S,Mouse NIH-3T3 |
| Dilution | WB 1:500-1:1000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant Human TIMP-2/TIMP2 protein expressed by E.coli |
| Abbre | TIMP-2/TIMP2 |
| Synonyms | Metalloproteinase inhibitor 2;CSC-21K;Tissue inhibitor of metalloproteinases 2 (TIMP-2);TIMP2 |
| Swissprot | |
| Calculated MW | 24 kDa |
| Observed MW | 24 kDa |
| Cellular Localization | Secreted |
| Tissue Specificity | Down-regulated by TGFB1 |
| Concentration | 1mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer;Cardiovascular;Cell Biology;Signal Transduction |
| Conjugation | Unconjugated |
| Background | Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family,TIMP-1,TIMP-2,TIMP-3,and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types,which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities. |
Western blot with TIMP-2/TIMP2 Polyclonal antibody at dilution of 1:1000.lane 1:Hela whole cell lysate,lane 2:SH-SY5Y whole cell lysate,lane 3:A431 whole cell lysate,lane 4:C6 whole cell lysate,lane 5:U-20S whole cell lysate,lane 6:NIH-3T3 whole cell lysate
