XAB2 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主： Rabbit
- 反应性： Human; Mouse; Rat
- 应用性： WB;IHC
| Verified Samples |
Verified Samples in WB:293T Verified Samples in IHC:Human colorectal cancer,Human liver cancer |
| Dilution | WB 1:500-1:2000;IHC 1:25-1:100 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide of human XAB2 |
| Abbre | XAB2 |
| Synonyms | 0610041O14Rik;adapter protein ATH 55;Adapter protein ATH-55;Ath55;AV025587;Crn related protein kim1 ;crn-related protein kim1;DKFZp762C1015;HCNP;HCNP protein;HCRN;KIAA1177;NTC90;PP3898;Pre-mRNA-splicing factor SYF1;Protein HCNP;RNA splicing factor;SYF1;SYF1 homolog;SYF1 homolog; RNA splicing factor ;SYF1 pre mRNA splicing factor;SYF1;Xab2;XPA binding protein 2;XPA-binding protein 2 |
| Swissprot | |
| Calculated MW | 100 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Nucleus. Detected in the splicing complex carrying pre-mRNA. |
| Concentration | 0.4 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Background | HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR? and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy. |
Western blot analysis of 293T cell lysates using XAB2 Polyclonal Antibody at dilution of 1:250
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using XAB2 Polyclonal Antibody at dilution of 1:25(×200)
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using XAB2 Polyclonal Antibody at dilution of 1:25(×200)
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| E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500μL , 120μL , 1mL |
| E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
| E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
| E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
