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TGF-β Signaling Pathway

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TGF-βs,Activins Cell Adhesion Translation control and cell-cycle transformation Cene Expression Cell proliferation Differentiation Survival Apoptosis Stress fiber BMP-2,4,7,MIS Type Ⅱ Receptor Type Ⅱ Receptor Type Ⅰ Receptor Type Ⅰ Receptor Shc GRB2 PP2A PARD6 Cofilin SMAD2/3 SMAD2/3 SMAD2/3 SMAD2/3 PMEPA1 SMAD7 SMAD4 SMAD4 SMAD4 SMAD4 Co-Act SMAD4 Co-Act Co-Act: CBP/P300 SMIF MGG1 ARC105 SMAD7 SMAD1/5/8 SMAD1/5/8 SMAD1/5/8 SMAD1/5/8 SMAD1/5/8 SMAD1/5/8 SMAD2/3 SMAD2/3 TF TF SARA SOS PI3K RAS AKT P38 JNK PKC PAK MTOR ROCK RHOA RAC/CDC42 LIMK ABL1 P70S6K MAP3K7/ MAP3K11/ MAP2K1/ MAP2K4 MAP2K3/6 ERK1/2