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MIγ/CXCL9 Polyclonal Antibody

MIγ/CXCL9 Polyclonal Antibody
  • MIγ/CXCL9 Polyclonal Antibody
  • MIγ/CXCL9 Polyclonal Antibody

Price: ¥2100.00 ¥800.00

Size:
100 μL 25 μL
  • 宿主: Rabbit
  • 反应性: Mouse;Rat
  • 应用性: WB
Verified Samples
Verified Samples in WB: Mouse brain, Rat brain
Dilution
WB 1:500-1:1000
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant Mouse MIγ/CXCL9 protein expressed by E.coli
Abbre
MIγ/CXCL9
Synonyms
C-X-C motif chemokine 9, Cxcl9, Gamma-interferon-induced monokine, Mig, Monokine induced by interferon-gamma (MIG, MuMIG), Protein m119, Scyb9, Small-inducible cytokine B9
Swissprot
Calculated MW
14 kDa
Observed MW
15 kDa
Cellular Localization
Nucleus
Tissue Specificity
By interferon gamma
Concentration
1 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
Purification Method
Antigen Affinity Purification
Research Areas
Epigenetics and Nuclear Signaling, Cancer, CellBiology, Neuroscience, Signal Transduction, Developmental Biology, Immunology
Conjugation
Unconjugated
Background
Chemokine (C-X-C motif) ligand 9 (CXCL9),also known as Monokine induced by gamma interferon (MIG),is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined;however,it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG,together with CXCL10 and CXCL11,may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth,movement,or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all,and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV,MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG,and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.
Western blot with MIγ/CXCL9 Polyclonal antibody at dilution of 1:1000.lane 1:Mouse brain,lane 2:Rat brain
E-AB-1003 Goat Anti-Rabbit IgG(H+L)(peroxidase/HRP conjugated) 500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1043 Streptavidin(peroxidase/HRP conjugated) 500 μL , 120 μL , 60 μL , 30 μL , 1 mL
E-AB-1194 HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed 500 μL , 120 μL , 1 mL
E-IR-R304A Western Blot Detection Kit 50 Assays
E-IR-R304B High Accuracy and Absorbability Western Blot Detection Kit 50 Assays


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