PE Anti-Human CD23 Antibody[EBVCS2]
Price:
Size:
100Tests
20Tests
100Tests×2
- 应用性： FCM
- 亚型： Mouse IgG1, κ
- 宿主： Mouse
| Background | CD23 is a 45 kD protein, also known as Leu-20, FcεRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15% of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region. |
| Alternate Names | Leu-20;FcεRII;IgE Fc Receptor;BLAST-2;B6;Low affinity IgE receptor |
| Swissprot | |
| Gene ID | |
| Clone No | |
| Host | Mouse |
| Reactivity | Human |
| Application | |
| Isotype | Mouse IgG1, κ |
| Isotype Control | |
| Conjugation | PE |
| Conjugation Information | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
| Spectrum |  |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration date | 12个月 |
| Shipping |
冰袋 |
Staining of normal human peripheral blood cells with APC Anti-Human CD19 Antibody and PE Anti-Human CD23 Antibody[EBVCS2] (left) or PE Mouse IgG1, κ Isotype Control (right). Cells in the lymphocytes gate were used for analysis.
