Recombinant Human Carboxypeptidase B2/CPB2 Protein (His Tag)
Price:
Size:
50μg
10μg
- 表达系统: HEK293 Cells
- 蛋白编码: NP_001863.3
别称 |
Carboxypeptidase B2;Carboxypeptidase U;CPU;Plasma Carboxypeptidase B;pCPB;Thrombin-Activable Fibrinolysis Inhibitor;TAFI;CPB2
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表达系统 |
HEK293 Cells
|
序列 |
Phe23-Val423
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蛋白编码 |
NP_001863.3
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种属 |
Human
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计算分子量 |
47.0 kDa
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表观分子量 |
55-65 kDa
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标签 |
C-His
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纯度 |
> 95 % as determined by reducing SDS-PAGE.
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内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM ZnCl2, 10% Glycerol, pH8.0.
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复溶方法 |
Not Applicable
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背景 |
Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. CPB2 exhibits carboxypeptidase activity when it is activated by proteolysis at residue Arg92 of the thrombin/thrombomodulin complex. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
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实验操作视频
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