Recombinant Human Carboxypeptidase E/CPE Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P16870
| 别称 |
Carboxypeptidase E(CPE for short);Carboxypeptidase H;Enkephalin convertase;Prohormone-processing carboxypeptidase
|
| 表达系统 |
HEK293 Cells
|
| 序列 |
Arg42-Ser453
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| 蛋白编码 |
P16870
|
| 种属 |
Human
|
| 计算分子量 |
47.2 kDa
|
| 表观分子量 |
50-60 kDa
|
| 标签 |
C-His
|
| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Histidine-HCl, 8% Sucrose, 2% Glycine, 20% Glycerol, 0.05% Tween 80, pH 6.5.
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| 复溶方法 |
Not Applicable
|
| 背景 |
The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.
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实验操作视频
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