Recombinant Human CD44 Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P16070
| 别称 |
CDW44;CSPG8;ECMR-III;HCELL;HUTCH-I;IN;LHR;MC56;MDU2;MDU3;MIC4;Pgp1;Epican;Extracellular Matrix Receptor III;ECMR-III;GP90 Lymphocyte Homing/Adhesion Receptor;HUTCH-I;Heparan Sulfate Proteoglycan;Hermes Antigen;Hyaluronate Receptor;Phagocytic Glycoprotein 1;PGP-1;Phagocytic Glycoprotein I;PGP-I;CD44
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln21-Pro220
|
| 蛋白编码 |
P16070
|
| 种属 |
Human
|
| 计算分子量 |
49.2 kDa
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| 表观分子量 |
75-95 kDa
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| 标签 |
C-Fc
|
| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
CD44 is a cell-surface receptor for hyaluronic acid and also interacts with other ligands; such as osteopontin; collagens; and matrix metalloproteinases. A large number of CD44 isoforms can be generated by the insertion of different combinations of at least nine exons. Increased CD44 antigen is associated with relapses in non-small cell lung cancers. Furthermore; an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium; stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one.
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实验操作视频
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