Recombinant Human FGF23 protein (SUMO,His tag)
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- 表达系统： E.coli
- 蛋白编码： Q9GZV9
| 别称 |
FGF-23;Fgf23;ADHR;FGF23;fibroblast growth factor 23;HPDR2;HYPF;phosphatonin;PHPTC
|
| 表达系统 |
E.coli
|
| 序列 |
Ala 24-Val 126
|
| 蛋白编码 |
Q9GZV9
|
| 种属 |
Human
|
| 计算分子量 |
31.2 kDa
|
| 表观分子量 |
32 kDa
|
| 标签 |
N-SUMO-His
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
Please contact us for more information.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
Fibroblast growth factor 23 (FGF?23) is a 30?32 kDa member of the FGF family, within a subfamily that also includes FGF?19 and FGF?21. FGF proteins contain a 120 amino acid (aa) core FGF domain that exhibits a beta ?trefoil structure. FGF?19 subfamily members are highly diffusible molecules owing to their poor ECM/heparin sulfate binding and plasma?stabilizing intramolecular folds. FGF?23 is produced by osteocytes and osteoblasts in response to high circulating phosphate levels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressing circulating phosphate levels . FGF?23 interaction with renal proximal tubular epithelium decreases the renal resorption of phosphate by down?regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinal absorption of phosphate.
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实验操作视频
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