Recombinant Human GITR/TNFRSF18 Protein (mFc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： Q9Y5U5
| 别称 |
Tumor necrosis factor receptor superfamily member 18;TNFRSF18;Glucocorticoid-induced TNFR-related protein;CD357;TNFRSF18;AITR;GITR
|
| 表达系统 |
HEK293 Cells
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| 序列 |
Gln26-Glu161(Thr45Ala)
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| 蛋白编码 |
Q9Y5U5
|
| 种属 |
Human
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| 计算分子量 |
41.1 kDa
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| 表观分子量 |
40-55 kDa
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| 标签 |
C-mFc
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| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1; TRAF2; and TRAF3; but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
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实验操作视频
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