Recombinant Human IL15RA/IL-15RA Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： Q13261-3
- 应用性： Cell culture
| 别称 |
CD215;IL15RA;CD215 antigen;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin 15 receptor;alpha;interleukin-15 receptor subunit alpha;MGC104179
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ile31-Thr172
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| 蛋白编码 |
Q13261-3
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| 种属 |
Human
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| 计算分子量 |
42.0 kDa
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| 表观分子量 |
60-75 kDa
|
| 标签 |
C-Fc
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| 生物活性 |
Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 0.35-3.5 ng/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.
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实验操作视频
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