Recombinant Human IL36G/IL1F9 Protein
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- 表达系统： E.coli
- 蛋白编码： Q9NZH8
- 应用性： Cell culture
| 别称 |
Interleukin-36 gamma;IL36G;IL-1-related protein 2;IL-1RP2;IL-1 epsilon;IL-1F9;Interleukin-1 homolog 1;IL-1H1;IL1E;IL1F9;IL1H1;IL1RP2
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| 表达系统 |
E.coli
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| 序列 |
Ser18-Asp169
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| 蛋白编码 |
Q9NZH8
|
| 种属 |
Human
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| 计算分子量 |
18.0 kDa
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| 表观分子量 |
19 kDa
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| 标签 |
C-His
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| 生物活性 |
Measure by its ability to induce IL-8 secretion in A431 cells.The ED50 for this effect is <5 ng/mL.
|
| 纯度 |
> 98 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 0.1 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from sterile PBS,pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). IL-36γ plays an important role in communicating the cell death to surrounding cells.
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实验操作视频
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