Recombinant Human Interleukin-15/IL-15 Protein
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- 表达系统： E.coli
- 蛋白编码： P40933
- 应用性： Cell culture
| 别称 |
IL-15;Interleukin 15;IL15
|
| 表达系统 |
E.coli
|
| 序列 |
Asn49-Ser162
|
| 蛋白编码 |
P40933
|
| 种属 |
Human
|
| 计算分子量 |
13.7 kDa
|
| 表观分子量 |
13 kDa
|
| 标签 |
N-His
|
| 生物活性 |
Measure by its ability to induce proliferation in CTLL-2 cells. The ED50 for this effect is < 3 ng/mL. The specific activity of recombinant human IL-15 is > 2 x 106 IU/mg.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.01 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from sterile PBS,pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
Human Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature Human IL-15 shares 70% amino acid sequence identity with Mouse and Rat IL-15.
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实验操作视频
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