Recombinant Human KIR2DL3 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P43628
| 别称 |
Killer Cell Immunoglobulin-Like Receptor 2DL3;CD158 Antigen-Like Family Member B2;KIR-023GB;Killer Inhibitory Receptor cl 2-3;MHC Class I NK Cell Receptor;NKAT2a;NKAT2b;Natural Killer-Associated Transcript 2;NKAT-2;p58 Natural Killer Cell Receptor Clone CL-6;p58 NK Receptor CL-6;p58.2 MHC Class-I-Specific NK Receptor;CD158b2;KIR2DL3;CD158B2;KIRCL23;NKAT2;KIR-K7b;KIR-K7c;KIR2DS5;KIRCL23;MGC129943;NKAT;NKAT2;NKAT2A;NKAT2B
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| 表达系统 |
HEK293 Cells
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| 序列 |
His22-His245
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| 蛋白编码 |
P43628
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| 种属 |
Human
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| 计算分子量 |
25.4 kDa
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| 表观分子量 |
35-50 kDa
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| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.
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实验操作视频
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