Recombinant Human LAG3/CD223 Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P18627
- 应用性： ELISA
| 别称 |
Lymphocyte activation gene 3 protein;LAG3;LAG-3;Protein FDC;CD223;LAG-3
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| 表达系统 |
HEK293 Cells
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| 序列 |
Leu23-Leu450
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| 蛋白编码 |
P18627
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| 种属 |
Human
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| 计算分子量 |
73.3 kDa
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| 表观分子量 |
70-90 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Immobilized Anti-Human LAG-3 mAb at 2μg/ml (100 μl/well)can bind Human LAG-3-Fc. The ED50 of Human LAG-3-Fc is 6.76 ng/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM NaH2PO4, 150mM NaCl, 0.1M Arginine, 0.1M Glu, 10% Glycerol, 0.01% Tween20, 5% Trehalose, pH 7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
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实验操作视频
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