Recombinant Human Legumain/LGMN Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： AAH03061.1
| 别称 |
Legumain;Asparaginyl Endopeptidase;Protease Cysteine 1;LGMN;PRSC1
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Ile18-Tyr433
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| 蛋白编码 |
AAH03061.1
|
| 种属 |
Human
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| 计算分子量 |
48.7 kDa
|
| 表观分子量 |
56 kDa
|
| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
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| 复溶方法 |
Not Applicable
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| 背景 |
Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
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实验操作视频
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