Recombinant Human LEPR (C-Fc)
Price:
- 表达系统： HEK293 Cells
- 蛋白编码： P48357
| 别称 |
Leptin receptor;LEP-R;HuB219;OB receptor;OB-R;CD295;LEPR;DB;OBR
|
| 表达系统 |
HEK293 Cells
|
| 序列 |
Phe22-Asp839
|
| 蛋白编码 |
P48357
|
| 种属 |
Human
|
| 计算分子量 |
120.4 kDa
|
| 表观分子量 |
150-180 kDa
|
| 标签 |
C-Fc
|
| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.
|
实验操作视频
新品推荐
Recombinant Human IL-6 Protein (Fc Tag)
Recombinant Mouse BCR protein (His tag)
Recombinant Mouse IL6 protein(His tag)
Recombinant Rat IL2/IL-2/Interleukin-2 protein (His tag)
Recombinant SARS-CoV-2 Nucleocapsid Protein (His Tag)
Recombinant Human Fyn protein(His tag)
Recombinant Mouse CD96/TACTILE protein (His tag)
