Recombinant Human LMCD1/Dyxin Protein (His Tag)
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- 表达系统: E.coli
- 蛋白编码: Q9NZU5
别称 |
LIM and cysteine-rich domains protein 1;LMCD1;Dyxin
|
表达系统 |
E.coli
|
序列 |
Met 1-Ser365
|
蛋白编码 |
Q9NZU5
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种属 |
Human
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计算分子量 |
44.0 kDa
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表观分子量 |
45 kDa
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标签 |
N-His & C-His
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纯度 |
> 95 % as determined by reducing SDS-PAGE.
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内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0.
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复溶方法 |
Not Applicable
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背景 |
LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
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实验操作视频
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