Recombinant Human UBE2G2 Protein (GST Tag)
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- 表达系统： E.coli
- 蛋白编码： P60604
| 别称 |
Ubiquitin-Conjugating Enzyme E2 G2;Ubiquitin Carrier Protein G2;Ubiquitin-Protein Ligase G2;UBE2G2
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| 表达系统 |
E.coli
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| 序列 |
Met 1-Leu165
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| 蛋白编码 |
P60604
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| 种属 |
Human
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| 计算分子量 |
45.0 kDa
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| 表观分子量 |
43 kDa
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| 标签 |
N-GST
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
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| 复溶方法 |
Not Applicable
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| 背景 |
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
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实验操作视频
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