Recombinant Mouse CD74 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P04441-2
| 别称 |
Cluster of Differentiation 74;CD74 antigen;CD74 molecule;major histocompatibility complex;class II invariant chain;DHLAG gamma chain of class II antigens;HLA class II histocompatibility antigen gamma chain;HLADG;HLA-DR antigens-associated invariant chain;HLA-DR-gamma;Ia antigen-associated invariant chain;Ia-associated invariant chain;Ia-GAMMA;MHC HLA-DR gamma chain;CD74;DHLAG;HLADG;Ia-gamma;INVG34;
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln56-Leu215
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| 蛋白编码 |
P04441-2
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| 种属 |
Mouse
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| 计算分子量 |
19.4 kDa
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| 表观分子量 |
25-30 kDa
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| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane glycoprotein which contains 1 thyroglobulin type-1 domain. Mouse CD74 shares 75% and 88% aa sequence identity with human and rat CD74, respectively. CD74 plays an important role in adaptive immunity, inflammation, and cancer. It plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.CD74 also associates with CD44 and binds with high affinity to the cytokine MIF, leading to inflammatory leukocyte responses, protection from tissue fibrosis, B cell proliferative and survival signaling, and the up-regulation of angiogenic factors in endometrial stromal cells.
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实验操作视频
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