Recombinant Mouse FGA/Fibrinogen A protein (His tag)
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- 表达系统: E.coli
- 蛋白编码: E9PV24
别称 |
FGA;Fib2;Fibrinogen A;Fibrinogen alpha chain;Fibrinogen Type I;fibrinogen;A alpha polypeptide;FPA
|
表达系统 |
E.coli
|
序列 |
Asp 434-Gln 789
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蛋白编码 |
E9PV24
|
种属 |
Mouse
|
计算分子量 |
39.1 kDa
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表观分子量 |
50 kDa
|
标签 |
N-His
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纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
内毒素 |
Please contact us for more information.
|
保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
制剂 |
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
复溶方法 |
Please refer to the printed manual for detailed information.
|
背景 |
Fibrinogen is a 340 kDa, secreted glycoprotein complex that is found in blood at concentrations of 150-400 mg/dL. It is secreted primarily by hepatocytes, but is also reported to be expressed by fibroblasts, type I alveolar epithelium, intestinal epithelium and some tumor cells. Fibrinogen is a homodimer that is composed of two, three-polypeptide chain subunits. Fibrinogen plays a central role in clot formation. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Fibrinogen is also a component of the ECM and binds to cell surface molecules on inflammatory cells. Mature mouse alpha, beta and gamma -chains share 67%, 85% and 83% aa identity with human alpha, beta and gamma -chains, respectively.
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实验操作视频
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