Recombinant Rhesus macaque IFNAR1 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： XP_005548864.1
| 别称 |
Alpha-type antiviral protein;AVP;beta-type antiviral protein;CRF2-1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC;IFN-alpha/beta R1;IFN-alpha/beta receptor 1;IFN-alpha-REC;IFNAR;IFNAR1;IFN-aR1;IFNBR;IFNbR1;IFN-bR1;IFN-R-1
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| 表达系统 |
HEK293 Cells
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| 序列 |
Ala25-Lys437
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| 蛋白编码 |
XP_005548864.1
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| 种属 |
Rhesus macaque
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| 计算分子量 |
48.4 kDa
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| 表观分子量 |
70-120 kDa
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| 标签 |
C-His
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Interferon?alpha/beta receptor 1 (IFN? alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
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实验操作视频
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