AMACR Polyclonal Antibody
Price:
Size:
100μL
50μL
- 宿主: Rabbit
- 反应性: Human
- 应用性: WB;IHC
Verified Samples |
Verified Samples in WB:Rat kidney,Rat liver,Rat intestine,Mouse kidney,Mouse liver Verified Samples in IHC:Mouse kidney,Mouse kidney,Human kidney |
Dilution | WB 1:1000-1:3000, IHC 1:150-1:300 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Mouse Amacr protein expressed by E.coli |
Abbre | AMACR |
Synonyms | 2 methylacyl CoA racemase; 2-methylacyl-CoA racemase; Alpha methylacyl CoA racemase; Alpha-methylacyl-CoA racemase; Amacr; AMACR; AMACRD; Macr1; RACE; RM |
Swissprot | |
Calculated MW | 42 kDa |
Observed MW | 40 kDa |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH 7.4 |
Purification Method | Affinity purification |
Research Areas | Cell Biology; Metabolism; Signal Transduction |
Conjugation | Unconjugated |
Background | AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However,AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa,suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4). |
Western Blot analysis of Rat kidney and Rat liver using AMACR Polyclonal Antibody at dilution of 1:3000.
Western Blot analysis of Rat intestine, Mouse kidney and Mouse liver using AMACR Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Mouse kidney using AMACR Polycloanl Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Mouse kidney using AMACR Polycloanl Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human kidney using Amacr Polyclonal Antibody at dilution of 1:300
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |