HSPA5 Polyclonal Antibody

Verified Samples in WB:Hela,Jurkat,THP-1,HT-29,NIH/3T3,RAW264.7,Mouse lung

WB:1:500-1:1000

Polyclonal

IgG

Recombinant Human HSPA5 protein expressed by E.coli

HSPA5

HSPA5;GRP78;78 kDa glucose-regulated protein;Binding-immunoglobulin protein;Heat shock protein 70 family protein 5;Heat shock protein family A member 5 ;Immunoglobulin heavy chain-binding protein

72 kDa

75 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

Affinity purification

Cancer; Tags and Cell Markers

Unconjugated

Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen.Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate .Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR).In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1.