IFITM3 Polyclonal Antibody

Verified Samples in WB:Human Hela,Human 293 T,Mouse Liver,Mouse Heart,Rat Liver
Verified Samples in IHC:Rat kidney,Mouse lung,Human lung
Verified Samples in IF:Human Hela

WB 1:1000-1:2000, IHC 1:50-1:200, IF 1:100-1:400

Polyclonal

IgG

Recombinant Rat IFITM3 protein expressed by E.coli

IFITM3

1 8U;Fragilis;IFITM3;IFM3;Interferon induced transmembrane protein 3 (1 8U);Interferon Induced Transmembrane Protein 3;Interferon inducible;Interferon inducible protein 1 8U;Interferon Inducible Protein 15;Interferon Inducible Protein Homolog;Interferon-induced transmembrane protein 3;Interferon-inducible protein 1-8U;IP15

15 kDa

15 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

Affinity purification

Cancer; Developmental Biology; Stem Cells

Unconjugated

IFITM3,also named as interferon-inducible protein 1-8U,belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens,namely influenza A H1N1 virus,West Nile virus (WNV),and dengue virus,by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses,respectively. IFITM3,the most potent antiviral IFITM,was found to inhibit an uncharacterized early infectious event after VSV endocytosis,but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses,and modulate cellular tropism independently of viral receptor expression. This antibody recognizes both IFITM2 and IFITM3.