MAP2K2 Monoclonal Antibody
Price:
Size:
120μL
60μL
20μL
- 宿主： Mouse
- 反应性： Human;Mouse;Rat
- 应用性： WB
| Verified Samples |
Verified Samples in WB:Hela,3T3,Rat brain |
| Dilution | WB 1:500-1:2000;IHC 1:100-1:300;IP 1:200-1:500 |
| Clonality | Monoclonal |
| Isotype | IgG |
| Immunogen | Synthesized peptide derived from human MEK-2 around the non-phosphorylation site of T394. |
| Abbre | MEK2 |
| Synonyms | Cardiofaciocutaneous syndrome;CFC syndrome;CFC4;Dual specificity mitogen activated protein kinase kinase 2;Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;FLJ26075;MAP kinase kinase 2;map2k2;MAPK / ERK kinase 2;MAPK/ERK kinase 2;MAPKK 2;MAPKK2;MEK 2;MEK2;Microtubule associated protein kinase kinase 2;Mitogen activated protein kinase kinase 2;Mitogen activated protein kinase kinase 2 p45;MKK 2;MKK2;MP2K2;OTTHUMP00000165826;OTTHUMP00000165827;PRKMK 2;PRKMK2抗体 |
| Swissprot | |
| Observed MW | 45kDa |
| Cellular Localization | Cytoskeleton,microtubule,Cytosol,Endoplasmic reticulum,endoplasmic reticulum,Endosome,early endosome,late endosome,Extracellular region or secreted,extracellular region,Golgi apparatus,Golgi apparatus,Mitochondrion,Nucleus,Peroxisome,peroxisomal membrane,Plasma Membrane,cytoplasmic side of Plasma Membrane,Other locations:cell-cell junction,focal adhesion,perinuclear region of cytoplasm |
| Concentration | 1 mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
| Purification Method | Protein A purification |
| Research Areas | Cancer; Signal Transduction |
| Clone No. | 2C3 |
| Conjugation | Unconjugated |
| Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain using MAP2K2 Monoclonal Antibody at dilution of 1:2000.
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| E-IR-R304A | Western Blot Detection Kit | 50Assays |
| E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |
